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Noninvasive, continuous monitoring for early detection of cerebral bleeding and edema


The VIPS technology was invented at University of California at Berkeley by Drs. Boris Rubinsky and Cesar Gonzalez. VIPS exploits the changes in electrical properties of tissue as a result of small changes in fluids. These changes in electrical properties can be detected by measuring the frequency response of the phase angle between a transmitter and receiver antenna.

Learn about VIPS technology:

  • González, César A., and Boris Rubinsky. “Frequency dependence of phase shift in edema: a theoretical study with magnetic induction,” Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the. IEEE, 2006.
  • González, César A., and Boris Rubinsky. “The detection of brain oedema with frequency-dependent phase shift electromagnetic induction”, Physiological measurement 27.6 (2006): 539.
  • González, César A., and Boris Rubinsky. “A theoretical study on magnetic induction frequency dependence of phase shift in oedema and haematoma.” Physiological measurement 27.9 (2006): 829.
  • González, C. A., R. Rojas, and B. Rubinsky. “Circular and Magnetron Inductor/Sensor Coils to Detect Volumetric Brain Edema by Inductive Phase Shift.” 13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography. Springer Berlin Heidelberg, 2007.
  • Gonzalez, Cesar A., et al. “Inductive phase shift spectroscopy for volumetric brain edema detection: An experimental simulation.” Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE. IEEE, 2007.
  • González, César A., Liana Horowitz, and Boris Rubinsky. “In vivo inductive phase shift measurements to detect intraperitoneal fluid.” IEEE transactions on biomedical engineering 54.5 (2007): 953-956.
  • González, C. A., and B. Rubinsky. “Remote Volumetric Detection System for Determining Tissue Water Content Properties: A New Concept Based on Magnetic Induction and Cellular Phone Technology.”IX Simposio Mexicano de Cirugía Asistida por Computadora y Procesamiento de Imágenes Médicas/ MEXCAS (2008).
  • Rojas, R., B. Rubinsky, and C. A. Gonzalez. “The effect of brain hematoma location on volumetric inductive phase shift spectroscopy of the brain with circular and magnetron sensor coils: a numerical simulation study.” Physiological Measurement 29.6 (2008): S255.
  • Flores, Omar, Boris Rubinsky, and César A. González. “Experimental sensitivity study of inductive phase shift spectroscopy as non-invasive method for hypoperfusion vs bleeding volumetric detection in brain.” Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE. IEEE, 2008.
  • Blumrosen, Gaddi, B. Rubinsky, and C. A. Gonzalez. “New wearable body sensor for continuous diagnosis of internal tissue bleeding.” Wearable and Implantable Body Sensor Networks, 2009. BSN 2009. Sixth International Workshop on. IEEE, 2009.
  • Gonzalez, C. A., et al. “The detection of brain ischaemia in rats by inductive phase shift spectroscopy.” Physiological measurement 30.8 (2009): 809.
  • González, César A., Gaddi Blumrosen, and Boris Rubinsky. “Remote Monitoring of Internal Bleeding Based on Magnetic Induction and Cellular Phone Technology: A Potential Application in Poor Regions in México.” Test journal 14.2 (2010).
  • González, César A., et al. “Over-hydration detection in brain by magnetic induction spectroscopy.” Journal of Physics: Conference Series. Vol. 224. No. 1. IOP Publishing, 2010.
  • Blumrosen, Gaddi, et al. “Exploitation of electromagnetic radiation properties for medical diagnostic.” Microwaves, Communications, Antennas and Electronics Systems (COMCAS), 2011 IEEE International Conference on. IEEE, 2011.
  • Laufer, Shlomi, Stephen B. Solomon, and Boris Rubinsky. “Tissue characterization using electrical impedance spectroscopy data: a linear algebra approach.” Physiological Measurement 33.6 (2012): 997.
  • Gonzalez, Cesar A., et al. “Volumetric Electromagnetic Phase-Shift Spectroscopy of Brain Edema and Hematoma.” PloS one 8.5 (2013): e63223.
  • Atefi, Seyed Reza, et al. “Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements.” Sensors 13.8 (2013): 10074-10086.

Cerebrotech Fills an Important Unmet Clinical Need

There is a critical gap in diagnosing and monitoring patients with stroke, traumatic brain injury (TBI) or other brain injury. Most patients are monitored with CT or MRI, which only provide snapshots. Intracranial pressure (ICP) monitors and other existing types of monitors are invasive and are therefore only used in the most serious cases. So, most brain injury patients receive no direct monitoring of their brain fluids, and only receive periodic neurological exams, which can detect problems only once they become severe enough to cause a clinically detectible neurologic deficit. At that point the situation becomes urgent, aggressive emergency intervention may be required, and irreversible damage may have already occurred.

There is a significant, critical unmet clinical need for a simple, non-invasive, continuous monitoring system for detecting small changes in brain fluids, enabling earlier intervention. Cerebrotech has the answer

Watch how Cerebrotech fills a critical unmet need in neurology:

Board of Directors

Mitch Levinson

Founder, President & CEO

Mr. Levinson is a start-up medical device executive with over 30 years of experience developing and bringing revolutionary new products to market. Mr. Levinson started Cerebrotech Medical Systems in 2011 based on a technology developed at UC Berkeley. Mr. Levinson was the start-up President and CEO for Zeltiq Aesthetics (ZLTQ), and led the development of the groundbreaking cooling technology for non-invasive fat layer reduction. Prior to Zeltiq, Mr. Levinson was the start-up VP of R&D at Thermage, which utilizes radiofrequency energy to provide non-invasive skin tightening. Thermage held its IPO in 2006, and is now part of Valeant Pharmaceuticals. Mr. Levinson was also VP of R&D at BioSurgical Corporation, developer of a novel applicator for fibrin sealant, acquired in 2000 by Baxter International. Mr. Levinson has led the development of breakthrough products at Nellcor (patient monitoring), Baxter (in vitro diagnostics), ALCOA Intercon-X, and Hewlett Packard. Many of Mr. Levinson's innovations are represented in his 37 issued U.S. patents with more pending. He earned his B.S. in Engineering Sciences from University of California at San Diego and also holds a MS in Computer Systems from University of Phoenix.

Brian Laden, PhD

Board Member, Venture Partner at Tri-Star Technology Ventures

Dr. Laden co-founded TriStar Technology Ventures in 2009. Through his role at TriStar, he serves on the Board of Directors for Cerebrotech, NuSirt, Molecular Sensing and Diagnovus, and oversees TriStar’s interest in BioStable, TVA and GenomOncology. Prior to the founding of TriStar, Dr. Laden served as the Assistant Director in the Office of Technology Transfer and Enterprise Development at Vanderbilt University. Dr. Laden holds a doctorate in Toxicology from the University of Kentucky, a master’s degree in Environmental and Industrial Health from the University of Michigan and an undergraduate degree in biology from Penn State University.

Issie Rabinovitch

Board Member, Rabinovitch Ventures

Issie N. Rabinovitch is a partner at Cheyenne Capital, a venture capital firm, and sits on multiple boards of directors for his portfolio companies. Mr. Rabinovitch was the Chief Executive Officer of Mainsail Networks, a telecommunications company. He served as President and CEO of Micro Power Systems, Inc., a semiconductor products company. Mr. Rabinovitch was President of Berkeley International Capital Corporation, a venture capital firm, was President of Crowntek Software International, a software development and distribution company, and was at Xerox in various management roles. Mr. Rabinovitch holds a B.S. from McGill University and an MBA from Harvard.

Joseph Cook III

Board Member

Mr. Cook co-founded Mountain Group Partners in 2002. In addition to Cerebrotech, Mr. Cook currently serves on or has visitation rights to the board of directors of: Castle Biosciences,Lineagen, and MiNDERA. Mr. Cook previously served on or had visitation rights to the board of directors of: ABT Molecular Imaging, Clearside Biomedical (NASDAQ “CLSD”), Pathfinder Therapeutics, VenX, Diagnovus, and OnFocus Healthcare. Prior to his involvement with MGP, Mr. Cook was a Director, Private Placements in the Investment Banking Group of Robert W. Baird & Co., and was Vice President in the Investment Banking Group at J.C. Bradford & Co. Mr. Cook graduated with a B.A. in Economics from Davidson College.

Martin Dieck

Board Member

Mr. Dieck has co-founded and held senior management positions in four neuro-interventional companies, all of which were acquired by Medtronic, Covidien or Stryker. Currently Mr. Dieck is Chairman of Synchron, Inc. a neuro-interventional company developing a minimally invasive brain machine interface. Mr. Dieck was co-founder, Chairman and CEO of Lazarus Effect, which developed a next-generation stroke treatment device and was sold to Medtronic in 2015. He previously served as CEO and board member at Nfocus Neuromedical, and Concentric Medical. As a venture investor, Mr. Dieck was an Executive Director at DFJ-ePlanet and ePlanet Capital where he had direct responsibility for the med-tech portfolio. This portfolio included BodyMedia (sold to Aliphcom / Jawbone), Spinal Modulation (sold to St Jude Medical), Zonare (sold to Mindray), DirectFlow and Intrapace. Mr. Dieck is an inventor with over 30 issued and pending patents.  He received his BA in Biological Sciences from Willamette University and MBA from the University of California at Berkeley.

In the News

Mary Kay Bader, Distinguished Leader in Neuroscience Nursing, Joins Cerebrotech’s Scientific Advisory Board November 19th, 2015

“We are delighted to welcome yet another extraordinary clinician, researcher and patient care advocate to the ranks of our scientific advisors.” Read Article

Former President of the Congress of Neurological Surgeons, Dr. Nathan Selden, Joins Cerebrotech’s Scientific Advisory Board October 9th, 2015

“Dr. Selden brings a wealth of neurosurgical expertise and academic distinction to the already notable ranks of our clinical and scientific advisors.” Read Article

Cerebrotech Receives CE Mark for Non-Invasive Brain Monitor August 25th, 2015

Approval to market Cerebrotech's Intracranial Fluids (ICF™) Monitor in Europe paves the way for early commercial activity and European clinical studies. Read Article

Cerebrotech CEO Mitch Levinson Speaking at Medical Device Summit August 3rd, 2015

Mitch Levinson will be speaking to entrepreneurs, investors and regulators at ComplianceOnline conference in San Diego on September 17, 2015. Read Article

Cerebrotech Works with US and German Space Agencies on Trail-Blazing Brain Study June 30th, 2015

Cerebrotech’s Intracranial Fluids Monitor is a key element of this study, as the company collaborates with world-class researchers from academia, NASA (thru NSBRI) and the German Aerospace Center (DLR). Read Article

Wireless Helmet Detects Brain Trauma Spring, 2014

Baylor Innovations highlights VIPS technology as a “game-changer”, according to Baylor University Medical Center department chair, Dr. Michael Foreman. Read Article

Cerebrotech Recognized as Rice Alliance Life Science Company at 2014 Texas Life Science Forum February 26th, 2014

Cerebrotech was chosen by investors and industry experts as a “top-10” at this prestigious medical innovation event. Read Article

Preventive Care From Outer Space August 21st, 2013

NSBRI sees Cerebrotech as part of the medical kit that accompanies astronauts on space missions. Read Article

NSBRI SMARTCAP Overview: Space to Earth Medical Innovations June 12th, 2013

Cerebrotech CEO interviewed after receiving grant from National Space Biomedical Research Institute (NSBRI). Read Article

Are Sideline Brain Scanners About to Become a Reality? June 6th, 2013

Cerebrotech inventor and co-founder, Boris Rubinsky, expects his technology will be useful in detecting concussion. Read Article

Wireless signals could transform brain trauma diagnostics May 14th, 2013

University of California researchers describe results from Mexico study on TBI patients. Read Article

New Technology Uses Wireless Signals To Diagnose Traumatic Brain Injury May 14th, 2013

UC Berkeley researchers discuss new brain monitoring technology. Read Article

NSBRI Funds Cerebrotech to Accelerate Development of Brain Monitoring Device March 12th, 2013

Cerebrotech is selected from dozens of applicants as the recipient of the 2013 SmartCAP grant from the National Space Biomedical Research Institute in Houston. Read Article

TriStar Technology Ventures invests in Cerebrotech June 7th, 2012

Nashville healthcare venture firm TriStar Technology Ventures makes significant investment in start-up Cerebrotech Medical Systems. Read Article

Around Pleasanton: Local entrepreneur has vision for saving lives November 3rd, 2011

Cerebrotech Co-Founder and CEO talks about his career and his vision for Cerebrotech. Read Article

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