An innovative neurotechnology device company

Photo of the Cerebrotech brain-scanning device atop a mannequin head

Cerebrotech Medical Systems is an innovative medical device company focused on the development of portable neurotechnology solutions. When a patient is having a stroke, rapid assessment, triage and intervention can mean the difference between achieving full functional independence and living with permanent, debilitating brain function loss.

The Cerebrotech Visor is a noninvasive wireless device for assessing brain fluid distribution. The Visor uses low-power radio waves to detect bioimpedance asymmetry, including asymmetry associated with large acute ischemic stroke in patients undergoing neurologic assessment. In recent clinical studies, the Visor has been able to differentiate large strokes from small strokes with an accuracy over 90%.

“At Cerebrotech Medical Systems, our mission is to improve healthcare outcomes across the globe by minimizing treatment delays for patients undergoing neurologic assessment. This mission drives our strategy and our work every day.”

Mitch Levinson

President & CEO
Cerebrotech products are not available for sale.

Technology

Our core technology, Volumetric Impedance Phase-shift Spectroscopy (VIPS™), provides real-time assessment of brain fluid distribution for patients undergoing neurologic assessment, allowing earlier intervention to prevent further brain damage. The technology passes low-power electromagnetic waves through the brain, detecting small changes and asymmetries in its electrical properties to aid neurologic assessment in about 30 seconds. Rapid assessment may lead to early intervention, better outcomes, and reduced hospital costs.

VIPS technology has the potential to significantly improve patient outcomes and transform the paradigms for managing of life-threatening neurological events that can occur following serious neurologic conditions including stroke, traumatic brain injury, and brain surgery. The Cerebrotech Visor, is a non-invasive wireless neurological device designed for use as an aid to clinical assessment in conjunction with current standards of care.

Cerebrotech’s core intellectual property is licensed exclusively from the University of California at Berkeley.

  • Kellner, Christopher P., Sauvageau, Eric, Snyder, Kenneth V., Fargen, Kyle M., Arthur, Adam S., Turner, Raymond D., Alexandrov, Andrei V., “The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device.” Journal of neurointerventional surgery (2018): neurintsurg-2017. http://jnis.bmj.com/content/early/2018/03/06/neurintsurg-2017-013690
  • Venkatasubba Rao, C.P., Bershad, E.M., Calvillo, E. et al. “Real-time Noninvasive Monitoring of Intracranial Fluid Shifts During Dialysis Using Volumetric Integral Phase-Shift Spectroscopy (VIPS): A Proof-of-Concept Study.” Neurocrit Care 2017. https://doi.org/10.1007/s12028-017-0409-4
  • González, César A., and Boris Rubinsky. “Frequency dependence of phase shift in edema: a theoretical study with magnetic induction,” Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the. IEEE, 2006.
  • González, César A., and Boris Rubinsky. “The detection of brain oedema with frequency-dependent phase shift electromagnetic induction”, Physiological measurement 27.6 (2006): 539.
  • González, César A., and Boris Rubinsky. “A theoretical study on magnetic induction frequency dependence of phase shift in oedema and haematoma.”Physiological measurement 27.9 (2006): 829.
  • González, C. A., R. Rojas, and B. Rubinsky. “Circular and Magnetron Inductor/Sensor Coils to Detect Volumetric Brain Edema by Inductive Phase Shift.” 13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography. Springer Berlin Heidelberg, 2007.
  • Gonzalez, Cesar A., et al. “Inductive phase shift spectroscopy for volumetric brain edema detection: An experimental simulation.” Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE. IEEE, 2007.
  • González, César A., Liana Horowitz, and Boris Rubinsky. “In vivo inductive phase shift measurements to detect intraperitoneal fluid.” IEEE transactions on biomedical engineering 54.5 (2007): 953-956.
  • González, C. A., and B. Rubinsky. “Remote Volumetric Detection System for Determining Tissue Water Content Properties: A New Concept Based on Magnetic Induction and Cellular Phone Technology.”IX Simposio Mexicano de Cirugía Asistida por Computadora y Procesamiento de Imágenes Médicas/ MEXCAS (2008).
  • Rojas, R., B. Rubinsky, and C. A. Gonzalez. “The effect of brain hematoma location on volumetric inductive phase shift spectroscopy of the brain with circular and magnetron sensor coils: a numerical simulation study.” Physiological Measurement 29.6 (2008): S255.
  • Flores, Omar, Boris Rubinsky, and César A. González. “Experimental sensitivity study of inductive phase shift spectroscopy as non-invasive method for hypoperfusion vs bleeding volumetric detection in brain.” Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE. IEEE, 2008.
  • Blumrosen, Gaddi, B. Rubinsky, and C. A. Gonzalez. “New wearable body sensor for continuous diagnosis of internal tissue bleeding.” Wearable and Implantable Body Sensor Networks, 2009. BSN 2009. Sixth International Workshop on. IEEE, 2009.
  • Gonzalez, C. A., et al. “The detection of brain ischaemia in rats by inductive phase shift spectroscopy.” Physiological measurement 30.8 (2009): 809.
  • González, César A., Gaddi Blumrosen, and Boris Rubinsky. “Remote Monitoring of Internal Bleeding Based on Magnetic Induction and Cellular Phone Technology: A Potential Application in Poor Regions in México.” Test journal 14.2 (2010).
  • González, César A., et al. “Over-hydration detection in brain by magnetic induction spectroscopy.” Journal of Physics: Conference Series. Vol. 224. No. 1. IOP Publishing, 2010.
  • Blumrosen, Gaddi, et al. “Exploitation of electromagnetic radiation properties for medical diagnostic.” Microwaves, Communications, Antennas and Electronics Systems (COMCAS), 2011 IEEE International Conference on. IEEE, 2011.
  • Laufer, Shlomi, Stephen B. Solomon, and Boris Rubinsky. “Tissue characterization using electrical impedance spectroscopy data: a linear algebra approach.” Physiological Measurement 33.6 (2012): 997.
  • Gonzalez, Cesar A., et al. “Volumetric Electromagnetic Phase-Shift Spectroscopy of Brain Edema and Hematoma.” PloS one 8.5 (2013): e63223.
  • Atefi, Seyed Reza, et al. “Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements.” Sensors 13.8 (2013): 10074-10086.
Cerebrotech patents are covered by the following US patents:
  • US 8731636
  • US 8633033
  • US 8361391
  • US 8101421
  • US 7910374
  • US 7638341

Clinical Need

There is a critical, highly-visible unmet need for effective, accurate pre-hospital stroke triage in ambulances and emergency rooms, to distinguish between the different types of stroke. Early identification of large vessel occlusion (LVO), a specific type of stroke, will allow patients to be transported directly to a specialty stroke center for intervention to restore blood flow to the affected portion of the brain, and enable each patient to receive the optimal care for their needs.

Every 45-minute reduction in time to thrombectomy, the current standard of care for LVO, yields a 10% increase in patients with functional independence at 3 months.

Cerebrotech products are not available for sale.

Board of Directors

Martin Dieck

Executive Chairman

Mr. Dieck has co-founded and held senior management positions in four neuro-interventional companies, all of which were acquired by Medtronic, Covidien or Stryker. Currently Mr. Dieck is Chairman of Synchron, Inc. a neuro-interventional company developing a minimally invasive brain machine interface. Mr. Dieck was co-founder, Chairman and CEO of Lazarus Effect, which developed a next-generation stroke treatment device and was sold to Medtronic in 2015. He previously served as CEO and board member at Nfocus Neuromedical, and Concentric Medical. As a venture investor, Mr. Dieck was an Executive Director at DFJ-ePlanet and ePlanet Capital where he had direct responsibility for the med-tech portfolio. This portfolio included BodyMedia (sold to Aliphcom / Jawbone), Spinal Modulation (sold to St Jude Medical), Zonare (sold to Mindray), DirectFlow and Intrapace. Mr. Dieck is an inventor with over 30 issued and pending patents.  He received his BA in Biological Sciences from Willamette University and MBA from the University of California at Berkeley.

Mitch Levinson

Founder, President & CEO

Mr. Levinson is a start-up medical device executive with over 30 years of experience developing and bringing revolutionary new products to market. Mr. Levinson started Cerebrotech Medical Systems in 2011 based on a technology developed at UC Berkeley. Mr. Levinson was the start-up President and CEO for Zeltiq Aesthetics (ZLTQ), and led the development of the groundbreaking cooling technology for non-invasive fat layer reduction. Prior to Zeltiq, Mr. Levinson was the start-up VP of R&D at Thermage, which utilizes radiofrequency energy to provide non-invasive skin tightening. Thermage held its IPO in 2006, and is now part of Valeant Pharmaceuticals. Mr. Levinson was also VP of R&D at BioSurgical Corporation, developer of a novel applicator for fibrin sealant, acquired in 2000 by Baxter International. Mr. Levinson has led the development of breakthrough products at Nellcor (patient monitoring), Baxter (in vitro diagnostics), ALCOA Intercon-X, and Hewlett Packard. Many of Mr. Levinson's innovations are represented in his 37 issued U.S. patents with more pending. He earned his B.S. in Engineering Sciences from University of California at San Diego and also holds a MS in Computer Systems from University of Phoenix.

Brian Laden, PhD

Board Member, Venture Partner at Tri-Star Technology Ventures

Dr. Laden co-founded TriStar Technology Ventures in 2009. Through his role at TriStar, he serves on the Board of Directors for Cerebrotech, NuSirt, Molecular Sensing and Diagnovus, and oversees TriStar’s interest in BioStable, TVA and GenomOncology. Prior to the founding of TriStar, Dr. Laden served as the Assistant Director in the Office of Technology Transfer and Enterprise Development at Vanderbilt University. Dr. Laden holds a doctorate in Toxicology from the University of Kentucky, a master’s degree in Environmental and Industrial Health from the University of Michigan and an undergraduate degree in biology from Penn State University.

Issie Rabinovitch

Board Member, Rabinovitch Ventures

Issie N. Rabinovitch is a partner at Cheyenne Capital, a venture capital firm, and sits on multiple boards of directors for his portfolio companies. Mr. Rabinovitch was the Chief Executive Officer of Mainsail Networks, a telecommunications company. He served as President and CEO of Micro Power Systems, Inc., a semiconductor products company. Mr. Rabinovitch was President of Berkeley International Capital Corporation, a venture capital firm, was President of Crowntek Software International, a software development and distribution company, and was at Xerox in various management roles. Mr. Rabinovitch holds a B.S. from McGill University and an MBA from Harvard.

Joseph Cook III

Board Member

Mr. Cook co-founded Mountain Group Partners in 2002. In addition to Cerebrotech, Mr. Cook currently serves on or has visitation rights to the board of directors of: Castle Biosciences,Lineagen, and MiNDERA. Mr. Cook previously served on or had visitation rights to the board of directors of: ABT Molecular Imaging, Clearside Biomedical (NASDAQ “CLSD”), Pathfinder Therapeutics, VenX, Diagnovus, and OnFocus Healthcare. Prior to his involvement with MGP, Mr. Cook was a Director, Private Placements in the Investment Banking Group of Robert W. Baird & Co., and was Vice President in the Investment Banking Group at J.C. Bradford & Co. Mr. Cook graduated with a B.A. in Economics from Davidson College.

In the News

News Article: Portable device detects severe stroke in seconds with 92 percent accuracy

Medical Xpress, Medical University of South Carolina, March 26, 2018

Study Results: The VIPS device was able to differentiate severe stroke from minor strokes…

Journal of Neurointerventional Surgery, March 6, 2018

Press Release: Cerebrotech™ Visor Receives FDA Clearance

January 4, 2018

Press Release: Congressman Eric Swalwell Awards Cerebrotech Medical Systems Special Congressional Recognition for Innovation and Economic Growth

December 7, 2017

Press Release: Cerebrotech Receives CE Mark Approval for Bioimpedance Asymmetry Associated with Stroke

November 29, 2017

News Article: VIPS: Time is brain

ABC TV (Ivanhoe Broadcasting), October 5, 2017

Press Release: Cerebrotech Appoints Neurovascular Veteran Martin Dieck to Executive Chairman

September 6, 2017

News Article: Start-Up Spotlight: Cerebrotech Hopes To Launch Portable Stroke Test Device In 2018

Pharma Intelligence MedTech Insight, August 22, 2017

News Article: Visor That IDs Stroke Type

MedPage Today, July 28, 2017

News Article: Novel Device Shows Promise for Early Identification of Serious Strokes

Endovascular Today, July 26, 2017

Press Release: Mary Kay Bader, Distinguished Leader in Neuroscience Nursing, Joins Cerebrotech’s Scientific Advisory Board

November 19, 2015

Press Release: Former President of the Congress of Neurological Surgeons, Dr. Nathan Selden, Joins Cerebrotech’s Scientific Advisory Board

October 9, 2015

Press Release: Cerebrotech Receives CE Mark for Non-Invasive Brain Monitor

August 25, 2015

Announcement: Cerebrotech CEO Mitch Levinson Speaking at Medical Device Summit

Mitch Levinson will be speaking to entrepreneurs, investors and regulators at ComplianceOnline conference in San Diego on September 17, 2015.

August 3, 2015

Announcement: Cerebrotech Works with US and German Space Agencies on Trail-Blazing Brain Study

Cerebrotech’s Intracranial Fluids Monitor is a key element of this study, as the company collaborates with world-class researchers from academia, NASA (thru NSBRI) and the German Aerospace Center (DLR).

June 30, 2015

News Article: Wireless Helmet Detects Brain Trauma

Baylor Innovations highlights VIPS technology as a “game-changer”, according to Baylor University Medical Center department chair, Dr. Michael Foreman.

BREAKTHROUGHS, Spring, 2014

Press Release: Cerebrotech Recognized as Rice Alliance Life Science Company at 2014 Texas Life Science Forum

February 26, 2014

Video: NSBRI SMARTCAP Overview: Space to Earth Medical Innovations

YouTube via HonceOui.com, June 12, 2013

Announcement: Are Sideline Brain Scanners About to Become a Reality?

Cerebrotech inventor and co-founder, Boris Rubinsky, expects his technology will be useful in detecting concussion.

June 6, 2013

Announcement: Wireless signals could transform brain trauma diagnostics

University of California researchers describe results from Mexico study on TBI patients.

May 14, 2013

News Article: New Technology Uses Wireless Signals To Diagnose Traumatic Brain Injury

UC Berkeley researchers discuss new brain monitoring technology.

Medical Daily, May 14, 2013

Press Release: NSBRI Funds Cerebrotech to Accelerate Development of Brain Monitoring Device

Cerebrotech is selected from dozens of applicants as the recipient of the 2013 SmartCAP grant from the National Space Biomedical Research Institute in Houston.

March 12, 2013

Announcement: TriStar Technology Ventures invests in Cerebrotech

Nashville healthcare venture firm TriStar Technology Ventures makes significant investment in start-up Cerebrotech Medical Systems.

June 7, 2012

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